Incidental skin manifestation of trisomy 12 chronic lymphocytic leukemia

نویسندگان

چکیده

Chronic lymphocytic leukemia (CLL) is one of the most prevalent B-cell cancers for people over age 65. CLL commonly comorbid with trisomy 12, as reported in up to 20% cases. In our case, 12 was incidentally found on this patient. Its pathophysiology quite unclear but has played a role side effect profile CLL. Trisomy been shown have increased risk effects like thrombocytopenia, Richter transformation and hematological cancers. The goal case presentation discuss cutaneous manifestations look at that can play.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study.

Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cells of conventional cytogenetic preparations from eight patients and on morpholo...

متن کامل

Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia.

Cytogenetic studies (CG) of 475 chronic lymphocytic leukemia (CLL) cases showed trisomy 12 in 6.1% or 26% of patients with abnormal karyotypes. Fluorescence in situ hybridization (FISH) detected trisomy 12 in 35% of 117 CLL patients. Only 34.6% of cases detected by FISH were detected by CG. Twelve patients had low levels of trisomic cells (4% to 11%) relative to clonal B cells (47.5% to 86%), s...

متن کامل

Obinutuzumab-induced coagulopathy in chronic lymphocytic leukaemia with trisomy 12

Obinutuzumab, an afucosylated, type 2 anti-CD20 antibody, showed superior results to rituximab in a head-to-head comparison in combination with chlorambucil in the first-line treatment of chronic lymphocytic leukaemia (CLL) patients with comorbidities in the CLL11 trial (NCT01010061). Enhanced activity of obinutuzumab in this setting may reflect better binding to Fc receptors as well as the dir...

متن کامل

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...

متن کامل

Establishment of a New Epstein - Barr Virus - Immortalized Cell Line From Chronic Lymphocytic Leukemia With Trisomy of Chromosome 12

C HRONIC LYMPHOCYTIC LEUKEMIA (CLL) B cells are, in general, highly refractory to transformation by Epstein-Barr virus (EBV),’ and therefore, relatively few EBV-immortalized cell lines originating from CLL cells have been described.’4 In this paper we report the establishment of a novel EBV-transformed B cell line from the leukemic cells of a CLL patient that expressed surface u immunoglobulin....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: World Journal Of Advanced Research and Reviews

سال: 2023

ISSN: ['2581-9615']

DOI: https://doi.org/10.30574/wjarr.2023.17.2.0258